Performance Report - Biotech

EH Quantitative Directional Long

The strategy actively trades a curated universe of over 200 investible tickers with material or enabling exposure to biotechnology, taking positions based on a proprietary technical ranking derived from a multi-factor analysis of market action across multiple trading horizons.

Forward test from inception 2023/01/03 to 2026/07/31

Overview

Annualized Returns: 117.61% Average Win Size: 3,365.59
Maximum Drawdown: 16.52% Average Loss Size: 2,170.02
Return over Maximum Drawdown: 7.11 Win/Loss Size Ratio: 1.55
Sharpe Ratio (Annualized): 2.72 Number of Closed and Open Positions: 2310
Sortino Ratio (Annualized): -4.04 Average Trade Value: 34,275 USD
Number of Wins: 1218 Average Closed Trade Duration: 7.0 days
Number of Losses: 1092 Last Session Move: -5,868.50 (-0.31%), Baseline move: (0.70%)
Win/Loss Count Ratio: 1.12 (53% winners) Win Months(%) 88.4%
Includes 10 open positions with cash holdings of 1,064,392.82 USD

Cash holdings are equivalent to 58% of Total Strategy Value (1,834,645.82 USD) at this time.

Monthly Strategy Returns (%):

  Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Total
2023 31.7 -0.1 22.2 24.1 25.5 9.2 12.8 -6.3 4.5 0.1 14.7 15.2 153.6
2024 17 15.5 4.5 -2.1 3.2 1.5 5.5 3.5 0.7 4 6.6 1.2 61.1
2025 1.7 2.4 0.4 3.2 0.6 6.4 4 4.5 8.8 0.6 2.8 -0.1 35.3
2026 1.5 7 1.4 9.5 14.5 11 -2.7 0 0 0 0 0 42.2

Open Positions:

Symbol Name Entry Date # Shares Entry Price Present Price Move Max Move Days HeldPrice Trailing Stop Profit Annualized
TNDMTandem Diabetes Care2026-07-21460017.6219.5010.66%10.66%9 18.56 (4.8%)8,648.00284.5%
ORICOric Pharmaceuticals2026-07-27530012.1111.07-8.58%0.00%5 10.919 (1.4%)-5,512.00-412.2%
HALOHalozyme Therapeutics2026-07-2770082.4182.540.15%1.26%5 80.518 (2.4%)91.007.5%
PCRXPacira BioSciences2026-07-28240026.7826.41-1.38%0.70%4 25.532 (3.3%)-888.00-82.9%
BMRNBioMarin Pharmaceutical2026-07-28100061.0060.02-1.60%1.75%4 59.014 (1.7%)-980.00-96.3%
BBIOBridgeBio Pharma2026-07-2990085.4980.09-6.31%0.07%3 76.635 (4.3%)-4,860.00-505.3%
ADILAdial Pharmaceuticals2026-07-30258003.143.346.36%6.36%2 2.821 (15.5%)5,160.00764.3%
ANIKAnika Therapeutics Inc.2026-07-31530018.3319.285.18%5.18%1 17.332 (10.1%)5,035.001,243.8%
CORTCorcept Therapeutics Incorporat2026-07-31800118.11114.49-3.06%0.17%1 97.942 (14.5%)-2,896.00-735.5%
REGNRegeneron Pharmaceuticals2026-07-31100726.69762.634.94%4.94%1 710.845 (6.8%)3,594.001,186.9%
Total Value (USD) of 10 Open Positions:757,845.007,392.0039.9%

Closed Month-To-Date Performance:

Symbol Name # Shares Buy Date Buy Price Sell Date Sell Price Max Move DurationPrice Profit ROI
TRVITrevi Therapeutics, Inc.52002026-06-1715.572026-07-0118.1019.78%10 13,156.0016.2%
AGIOAgios Pharmaceuticals23002026-06-2234.302026-07-0137.0811.69%8 6,394.008.1%
RLAYRelay Therapeutics48002026-06-2316.652026-07-0118.4318.55%7 8,544.0010.7%
MGTXMeiraGTx54002026-06-2411.962026-07-0113.0812.95%6 6,048.009.4%
VKTXViking Therapeutics18002026-06-2435.632026-07-0138.2110.97%6 4,644.007.2%
DFTXDefinium Therapeutics, Inc.15002026-06-2541.992026-07-0145.1812.02%5 4,785.007.6%
RVMDRevolution Medicines3002026-06-26175.192026-07-01187.519.94%4 3,696.007%
ORKAOruka Therapeutics, Inc.9002026-06-2384.012026-07-0290.8413.28%8 6,147.008.1%
DNLIDenali Therapeutics36002026-06-1622.122026-07-0625.7718.58%13 13,140.0016.5%
MPLTMapLight Therapeutics, Inc.22002026-07-0135.482026-07-0636.294.53%3 1,782.002.3%
MNPRMonopar Therapeutics Inc.7002026-06-2482.042026-07-0796.1719.85%9 9,891.0017.2%
GHGuardant Health4002026-06-30151.922026-07-07165.4814.58%5 5,424.008.9%
MRNAModerna12002026-06-1863.962026-07-0876.8428.36%13 15,456.0020.1%
NUVBNuvation Bio115002026-06-255.622026-07-085.8714.94%9 2,875.004.4%
TXG10X Genomics21002026-07-0138.542026-07-0837.473.78%5 -2,247.00-2.8%
RAREUltragenyx Pharmaceutical24002026-07-0133.132026-07-0834.968.27%5 4,392.005.5%
ALDXAldeyra Therapeutics, Inc.337002026-07-022.412026-07-082.180.82%4 -7,751.00-9.5%
CLDXCelldex Therapeutics24002026-06-1833.692026-07-1039.1118.52%15 13,008.0016.1%
PTGXProtagonist Therapeutics5002026-06-24119.382026-07-10134.2717.98%12 7,445.0012.5%
CORTCorcept Therapeutics Incorporat7002026-06-3087.612026-07-1092.277.33%8 3,262.005.3%
ABSIAbsci Corporation57002026-06-3011.342026-07-1010.994.49%8 -1,995.00-3.1%
ZVRAZevra Therapeutics, Inc.56002026-07-0114.312026-07-1013.943.07%7 -2,072.00-2.6%
FHTXFoghorn Therapeutics Inc.154002026-07-065.272026-07-105.9517.07%5 10,472.0012.9%
VRTXVertex Pharmaceuticals Incorporated1002026-07-07530.002026-07-10491.770.00%4 -3,823.00-7.2%
ARWRArrowhead Pharmaceuticals9002026-07-0787.282026-07-1080.440.00%4 -6,156.00-7.8%
ORICOric Pharmaceuticals69002026-07-0611.642026-07-1310.620.00%6 -7,038.00-8.8%
ADUSAddus placeholder7002026-07-06105.162026-07-13108.868.79%6 2,590.003.5%
BCAXBicara Therapeutics Inc.27002026-07-0729.452026-07-1328.343.22%5 -2,997.00-3.8%
TRVITrevi Therapeutics, Inc.33002026-07-0819.512026-07-1317.560.00%4 -6,435.00-10%
MGTXMeiraGTx45002026-07-0814.442026-07-1313.001.52%4 -6,480.00-10%
RCKTRocket Pharmaceuticals155002026-07-094.172026-07-133.781.67%3 -6,045.00-9.4%
VVOSVivos Therapeutics, Inc.101908.7018552025-07-100.7012026-07-130.5251,204.34%253 -17,935.93-25.1%
LRMRLarimar Therapeutics, Inc.193002026-07-134.192026-07-143.772.14%2 -8,106.00-10%
NUVLNuvalent7002026-07-14123.972026-07-14123.960.00%1 -7.000%
ADUSAddus placeholder7002026-07-17112.892026-07-14117.285.60%1 3,073.003.9%
CORTCorcept Therapeutics Incorporat6002026-07-2295.182026-07-14118.3224.31%1 13,884.0024.3%
INCYIncyte5002026-07-28119.002026-07-14123.499.18%1 2,245.003.8%
FATEFate Therapeutics268002026-07-023.022026-07-152.992.98%9 -804.00-1%
ILMNIllumina4002026-07-07193.922026-07-15189.300.21%7 -1,848.00-2.4%
LGNDLigand Pharmaceuticals2002026-07-07317.972026-07-15299.131.33%7 -3,768.00-5.9%
ANABAnaptysBio13002026-07-1470.912026-07-1563.820.00%2 -9,217.00-10%
ACRSAclaris Therapeutics, Inc.144002026-07-065.632026-07-165.482.30%9 -2,160.00-2.7%
PSNLPersonalis64002026-07-1415.142026-07-1615.584.29%3 2,816.002.9%
TTRXTurn Therapeutics Inc.68002026-07-089.432026-07-179.123.28%8 -2,108.00-3.3%
JSPRJasper Therapeutics, Inc.1128002026-07-150.722026-07-170.88522.91%3 18,612.0022.9%
VYNEVYNE Therapeutics Inc.1136002026-07-150.7152026-07-170.767.41%3 5,112.006.3%
DFTXDefinium Therapeutics, Inc.13002026-07-0947.732026-07-2043.320.00%8 -5,733.00-9.2%
AKBAAkebia Therapeutics454002026-07-091.432026-07-201.310.00%8 -5,448.00-8.4%
ABEOAbeona Therapeutics Inc.138002026-07-147.052026-07-206.753.40%5 -4,140.00-4.3%
CORCencora, Inc.2002026-07-09301.522026-07-21303.072.66%9 310.000.5%
CYRXCryoPort, Inc.49002026-07-1616.382026-07-2116.241.15%4 -686.00-0.9%
TMOThermo Fisher Scientific Inc1002026-07-17539.102026-07-21523.460.75%3 -1,564.00-2.9%
INMBINmune Bio390002026-07-152.082026-07-221.910.00%6 -6,630.00-8.2%
SIONSionna Therapeutics, Inc.12002026-07-2050.202026-07-2245.980.00%3 -5,064.00-8.4%
MNPRMonopar Therapeutics Inc.7002026-07-13106.152026-07-23109.326.99%9 2,219.003%
DNTHDianthus Therapeutics, Inc.9002026-07-1499.852026-07-23104.795.87%8 4,446.004.9%
TRVITrevi Therapeutics, Inc.33002026-07-2019.282026-07-2317.350.00%4 -6,369.00-10%
VYNEVYNE Therapeutics Inc.742002026-07-230.8752026-07-240.6555.48%2 -16,324.00-25.1%
TXG10X Genomics17002026-07-1545.812026-07-2746.145.95%9 561.000.7%
BLFSBioLife Solutions, Inc.27002026-07-1730.002026-07-2729.833.86%7 -459.00-0.6%
APGEApogee Therapeutics, Inc.4002026-07-08133.522026-07-28134.250.59%15 292.000.5%
SYRESpyre Therapeutics, Inc.7002026-07-16103.322026-07-2899.960.00%9 -2,352.00-3.3%
IMCRImmunocore18002026-07-2034.752026-07-2833.652.27%7 -1,980.00-3.2%
BBNXBeta Bionics, Inc.46002026-07-2117.562026-07-2816.051.48%6 -6,946.00-8.6%
XNCRXencor43002026-07-2118.852026-07-2819.979.17%6 4,816.005.9%
IOVAIovance Biotherapeutics160002026-07-215.072026-07-284.848.48%6 -3,680.00-4.5%
BTMDBiotricity327002026-07-212.482026-07-282.292.01%6 -6,213.00-7.7%
DYNDyne Therapeutics34002026-07-1623.842026-07-2925.538.89%10 5,746.007.1%
NVONovo Nordisk A/S15002026-07-1751.062026-07-3147.401.07%11 -5,490.00-7.2%
NUVBNuvation Bio101002026-07-236.422026-07-316.514.36%7 909.001.4%
LQDALiquidia Corporation7002026-07-2386.222026-07-3185.184.91%7 -728.00-1.2%
RPRXRoyalty Pharma plc11002026-07-2358.682026-07-3158.532.19%7 -165.00-0.3%
NBIXNeurocrine Biosciences3002026-07-27176.462026-07-31176.175.12%5 -87.00-0.2%

Month-To-Date Summary:
MTD Win Trades %:47.9%
MTD Avg # Entry Trades per Day:2.5
MTD Avg # Positions Held:16.1
MTD Win/Loss Size Ratio:1.26
MTD Avg Trade Duration:9.6
MTD Strategy Performance:-3.7%
MTD Baseline (^GSPC) Performance:-0.1%
MTD Strategy Outperformance compared to Baseline:-3.6%
Sold Today:NVO, NUVB, LQDA, RPRX, NBIX
Pending Buys:ILMN, QNCX

Notes:

The performance data quoted represents past performance. Past performance does not guarantee future results. The investment return and principal value of an investment will fluctuate so that an investor's position, when redeemed, may be worth more or less than the original cost. Current performance may be lower or higher than the performance data quoted. Investors should consider the investment objectives, risks, and charges and expenses of the above system carefully before investing.

Last Session Date: 2026/07/31